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Good to see your images Nick.
Regarding focal length it depends what you want to see obviously but it also affects apparent movement of stars and therefore shutter speeds. The further the stars are from the pole star the quicker they appear to travel, again restricts shutter opening if you want to capture point sources as opposed to trails.
I went to 1600iso at one point but that setting introduced too much light pollution and noise, and anyway the best results I achieved that night were at 800iso (on a Canon 60d). I used the viewfinder to focus and stopped lens creep with a bit of blue tack.
Just to add, switch off long exposure noise reduction if you are using it.
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