Check the Adobe website for Adobe Acrobat which is their PDF program.
I'm not sure about other programs which produce PDF's, but with Acrobat you set the print up as if your are printing to a printer, but instead of selecting a printer you select Acrobat as your printer. This also means you need the profile of the printer that is the final destination. Once it set up as a PDF then it can't be changed unless you/they have Acrobat.