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Hi Howard we will need a bit more info on your kit and set up to be able to give you help with your close up work .
I think your using a 70 -300 lens but what make is it and if it's got VR / OS also I see your out at 300mm iso 1600 and 1/250's but I don't know the f number . With this type of lens you will never get the same pin sharp images that you would if you used a macro lens , any zoom lens will deliver softer images at its extreme reach .
Also shooting close up's at 300mm with a shutter speed of 1/250's any tiny movement by you or the subject will show up as a blurred image unless your using a tripod .
To start with make sure you have plenty of light to get your iso down and your shutter speed up .
Mark
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